Homolog pairing during meiosis: Dyneins on the move
نویسندگان
چکیده
منابع مشابه
HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
Repair of the programmed meiotic double-strand breaks (DSBs) that initiate recombination must be coordinated with homolog pairing to generate crossovers capable of directing chromosome segregation. Chromosome pairing and synapsis proceed independently of recombination in worms and flies, suggesting a paradoxical lack of coregulation. Here, we find that the meiotic axis component HTP-3 links DSB...
متن کاملInitiation of homologous chromosome pairing during meiosis.
Following pre-meiotic DNA replication, homologous chromosomes must be paired and become tightly linked to ensure reductional segregation during meiosis I. Therefore initiation of homologous chromosome pairing is vital for meiosis to proceed correctly. A number of factors contribute to the initiation of homologous chromosome pairing including telomere and centromere dynamics, pairing centres, ch...
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In preparation for meiotic chromosome segregation, homologous chromosomes need to pair, synapse (i.e., assemble the synaptonemal complex, SC), and then recombine to generate a physical linkage (i.e., chiasma) between them. In many organisms meiotic pairing capacity distributed along the entire chromosome length supports presynaptic alignment. In contrast, the prevailing model for C. elegans pro...
متن کاملThe Dynamics of Homologous Chromosome Pairing during Male Drosophila Meiosis
BACKGROUND Meiotic pairing is essential for the proper orientation of chromosomes at the metaphase plate and their subsequent disjunction during anaphase I. In male Drosophila melanogaster, meiosis occurs in the absence of recombination or a recognizable synaptonemal complex (SC). Due to limitations in available cytological techniques, the early stages of homologous chromosome pairing in male D...
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The alignment of homologous chromosomes that occurs early during prophase of meiosis usually occurs in two stages: a pairing stage where the homologs are roughly aligned and a synapsis stage where homologous chromosomes are aligned precisely and held together by a specialized structure, the synaptonemal complex (SC). Meiosis culminates in the segregation of homologous chromosomes that have been...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.11.11856